Bioinformatics

The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection
We characterize the intrinsically disordered bacterial effector protein Tir and find that it mimics human structural traits. An analysis of other effectors suggest that bacteria use structural disorder to attack its hosts.
Marta F.M. Vieira, Guillem Hernández, Tiago Veloso, Hugo Monteiro, Miguel Arbesú Andrés, Andreas Zanzoni, Tiago N. Cordeiro
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The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection
Integrating disorder in globular multidomain proteins: Fuzzy sensors and the role of SH3 domains
We argue that SH3 domains have the special capability of engaging in fuzzy complexes, acting as transducers between disordered and structured protein regions,
Miguel Arbesú Andrés, Miquel Pons
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