Fuzziness

Integrating disorder in globular multidomain proteins: Fuzzy sensors and the role of SH3 domains
We argue that SH3 domains have the special capability of engaging in fuzzy complexes, acting as transducers between disordered and structured protein regions,
Miguel Arbesú Andrés, Miquel Pons
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A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring
The intramolecular fuzzy complex is conserved upon and modulated by lipid binding in its native-like myristoylated form.
Anabel-Lise Le Roux, Irrem-Laareb Mohammad, Borja Mateos, Miguel Arbesú Andrés, Farman Ali Khan, João M.C. Teixeira, Miquel Pons
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A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring
Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
We generalize our findings regarding the c-Src intramolecular fuzzy complex and make the case that such interfaces are common in multidomain proteins.
Miguel Arbesú Andrés, Guillermo Iruela, Héctor Fuentes, João M.C. Teixeira, Miquel Pons
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Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
A novel regulatory unit in the N-terminal region of c-Src
The SH3 domain and the disordered N-terminus of c-Src comprise a novel regulatory unit, enabled by a dynamic yet specific intramolecular fuzzy complex that could be conserved in other related proteins.
Miguel Arbesú Andrés
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A novel regulatory unit in the N-terminal region of c-Src
The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases
The SH3 domain and the disordered N-terminus of c-Src form a dynamic yet specific intramolecular fuzzy complex that could be conserved in other related proteins.
Miguel Arbesú Andrés, Mariano Maffei, Tiago N. Cordeiro, João M.C. Teixeira, Yolanda Pérez, Pau Bernadó, Serge Roche, Miquel Pons
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The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases