Intrinsically Disordered Proteins

The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection
We characterize the intrinsically disordered bacterial effector protein Tir and find that it mimics human structural traits. An analysis of other effectors suggest that bacteria use structural disorder to attack its hosts.
Marta F.M. Vieira, Guillem Hernández, Tiago Veloso, Hugo Monteiro, Miguel Arbesú Andrés, Andreas Zanzoni, Tiago N. Cordeiro
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The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection
Integrating disorder in globular multidomain proteins: Fuzzy sensors and the role of SH3 domains
We argue that SH3 domains have the special capability of engaging in fuzzy complexes, acting as transducers between disordered and structured protein regions,
Miguel Arbesú Andrés, Miquel Pons
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A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring
The intramolecular fuzzy complex is conserved upon and modulated by lipid binding in its native-like myristoylated form.
Anabel-Lise Le Roux, Irrem-Laareb Mohammad, Borja Mateos, Miguel Arbesú Andrés, Farman Ali Khan, João M.C. Teixeira, Miquel Pons
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A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring
Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
We generalize our findings regarding the c-Src intramolecular fuzzy complex and make the case that such interfaces are common in multidomain proteins.
Miguel Arbesú Andrés, Guillermo Iruela, Héctor Fuentes, João M.C. Teixeira, Miquel Pons
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Intramolecular Fuzzy Interactions Involving Intrinsically Disordered Domains
A novel regulatory unit in the N-terminal region of c-Src
The SH3 domain and the disordered N-terminus of c-Src comprise a novel regulatory unit, enabled by a dynamic yet specific intramolecular fuzzy complex that could be conserved in other related proteins.
Miguel Arbesú Andrés
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A novel regulatory unit in the N-terminal region of c-Src
The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases
The SH3 domain and the disordered N-terminus of c-Src form a dynamic yet specific intramolecular fuzzy complex that could be conserved in other related proteins.
Miguel Arbesú Andrés, Mariano Maffei, Tiago N. Cordeiro, João M.C. Teixeira, Yolanda Pérez, Pau Bernadó, Serge Roche, Miquel Pons
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The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases
The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src
The SH3 domain of c-Src interacts with the disordered N-terminus
Mariano Maffei, Miguel Arbesú Andrés, Anabel-Lise Le Roux, Irene Amata, Serge Roche, Miquel Pons
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The SH3 Domain Acts as a Scaffold for the N-Terminal Intrinsically Disordered Regions of c-Src
Lipid binding by disordered proteins
A protocol to study how intrinsically disordered proteins bind to lipids.
Mariano Maffei, Irene Amata, Miguel Arbesú Andrés, Yolanda Pérez, Miquel Pons
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