Hello
My name is Miguel. I am a researcher working at the intersection between Biology and Artificial Intelligence.
Nowadays I am interested in AI-powered protein engineering and optimization problems. I specialize in designing flexible proteins that challenge structure-based modeling.
Interests
- Protein Engineering
- Optimization
- Immunology
Education
PhD in Organic Chemistry, 2018
University of Barcelona, Spain
MSc in Organic Chemistry, 2013
University of Barcelona, Spain
BSc, MSc in Chemistry, 2012
University of Oviedo, Spain
Experience
Senior applied research scientist
Develop and apply state-of-the-art methods in protein engineering and other optimization problems.
Research engineer
Visiting researcher
Helmholtz Information & Data Science Academy (HIDA) grantee at the MDC Bioinformatics unit.
Projects:
- Protein:drug interaction prediction with geometric deep learning and protein language models.
Postdoctoral researcher
Projects:
- Liquid-liquid phase separation of human FUS by solid state Nuclear Magnetic Resonance .
- Regulation of plant salt-stress response by phosphorylation of protein CC1.
- Structural disorder in enteropathogenic bacterial proteomes.
Tasks:
- Method development
- Solid state and solution Nuclear Magnetic Resonance data acquisition
- Data analysis
PhD student
Thesis: A novel regulatory unit in the N-terminal region of c-src.
Tasks:
- Protein expression and purification.
- Solution Nuclear Magnetic Resonance data acquisition.
- Data analysis.
Latest publications
(2025).
GeoGraph: Geometric and Graph-based Ensemble Descriptors for Intrinsically Disordered Proteins.
In Arxiv. Accepted in the NeurIPS 2025 AI for Science and Machine Learning and the Physical Sciences workshops.
(2024).
Generative Model for Small Molecules with Latent Space RL Fine-Tuning to Protein Targets.
In Arxiv.
(2023).
Offline RL for generative design of protein binders.
In BioRxiv. Accepted in the NeurIPS 2023 New Frontiers of AI for Drug Discovery and Development workshop.
Upcoming & Past Talks
Contact
- miguelarbesu@gmail.com
- Berlin, Berlin 10115